Clozapine in the treatment of parkinsonian patients with dopaminomimetic psychosis
Identifieur interne : 004A04 ( Main/Exploration ); précédent : 004A03; suivant : 004A05Clozapine in the treatment of parkinsonian patients with dopaminomimetic psychosis
Auteurs : E. C. Wolters ; T. A. Hurwitz ; E. Mak ; P. Teal ; F. R. Peppard ; R. Remick ; S. Calne ; D. B. CalneSource :
- Neurology [ 0028-3878 ] ; 1990.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Psychiatrie, Homme.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Antiparkinson agent, Chemotherapy, Clozapine (therapeutic use), Degenerative disease, Dibenzazepines (therapeutic use), Dopamine Agents (adverse effects), Dopamine agonist, Double-Blind Method, Female, Human, Humans, Male, Middle Aged, Nervous system diseases, Neuroleptic, Parkinson Disease (drug therapy), Parkinson Disease (psychology), Parkinson disease, Prevention, Psychiatric Status Rating Scales, Psychiatry, Psychoses, Substance-Induced (etiology), Psychoses, Substance-Induced (prevention & control), Psychotropic, Randomized Controlled Trials as Topic, Sleep (drug effects), Toxic psychosis, Toxicity, Treatment.
- MESH :
- chemical , adverse effects : Dopamine Agents.
- chemical , therapeutic use : Clozapine, Dibenzazepines.
- drug effects : Sleep.
- drug therapy : Parkinson Disease.
- etiology : Psychoses, Substance-Induced.
- prevention & control : Psychoses, Substance-Induced.
- psychology : Parkinson Disease.
- Aged, Aged, 80 and over, Double-Blind Method, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Randomized Controlled Trials as Topic.
Abstract
In a double-blind placebo-controlled study, we evaluated the effects of clozapine (75 to 250 mg/day, mean 170.8) on dopaminomimetic psychosis and parkinsonian disability. Clozapine prevented deterioration of psychosis during the increase of dopaminomimetics in the 3 patients who completed the study. Worsening of parkinsonism occurred in 3 of 6 patients
Affiliations:
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Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antiparkinson agent</term>
<term>Chemotherapy</term>
<term>Clozapine (therapeutic use)</term>
<term>Degenerative disease</term>
<term>Dibenzazepines (therapeutic use)</term>
<term>Dopamine Agents (adverse effects)</term>
<term>Dopamine agonist</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Human</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Neuroleptic</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (psychology)</term>
<term>Parkinson disease</term>
<term>Prevention</term>
<term>Psychiatric Status Rating Scales</term>
<term>Psychiatry</term>
<term>Psychoses, Substance-Induced (etiology)</term>
<term>Psychoses, Substance-Induced (prevention & control)</term>
<term>Psychotropic</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Sleep (drug effects)</term>
<term>Toxic psychosis</term>
<term>Toxicity</term>
<term>Treatment</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Dopamine Agents</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Clozapine</term>
<term>Dibenzazepines</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Sleep</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Psychoses, Substance-Induced</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Psychoses, Substance-Induced</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Psychiatric Status Rating Scales</term>
<term>Randomized Controlled Trials as Topic</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Psychose toxique</term>
<term>Stimulant dopaminergique</term>
<term>Antiparkinsonien</term>
<term>Clozapine</term>
<term>Neuroleptique</term>
<term>Psychotrope</term>
<term>Toxicité</term>
<term>Parkinson maladie</term>
<term>Maladie dégénérative</term>
<term>Psychiatrie</term>
<term>Système nerveux pathologie</term>
<term>Prévention</term>
<term>Traitement</term>
<term>Homme</term>
<term>Chimiothérapie</term>
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<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Psychiatrie</term>
<term>Homme</term>
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<front><div type="abstract" xml:lang="en">In a double-blind placebo-controlled study, we evaluated the effects of clozapine (75 to 250 mg/day, mean 170.8) on dopaminomimetic psychosis and parkinsonian disability. Clozapine prevented deterioration of psychosis during the increase of dopaminomimetics in the 3 patients who completed the study. Worsening of parkinsonism occurred in 3 of 6 patients</div>
</front>
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<affiliations><list></list>
<tree><noCountry><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D. B." last="Calne">D. B. Calne</name>
<name sortKey="Calne, S" sort="Calne, S" uniqKey="Calne S" first="S." last="Calne">S. Calne</name>
<name sortKey="Hurwitz, T A" sort="Hurwitz, T A" uniqKey="Hurwitz T" first="T. A." last="Hurwitz">T. A. Hurwitz</name>
<name sortKey="Mak, E" sort="Mak, E" uniqKey="Mak E" first="E." last="Mak">E. Mak</name>
<name sortKey="Peppard, F R" sort="Peppard, F R" uniqKey="Peppard F" first="F. R." last="Peppard">F. R. Peppard</name>
<name sortKey="Remick, R" sort="Remick, R" uniqKey="Remick R" first="R." last="Remick">R. Remick</name>
<name sortKey="Teal, P" sort="Teal, P" uniqKey="Teal P" first="P." last="Teal">P. Teal</name>
<name sortKey="Wolters, E C" sort="Wolters, E C" uniqKey="Wolters E" first="E. C." last="Wolters">E. C. Wolters</name>
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